Evening Primrose Oil

100 & 200 soft-gel capsules

with Certified Organic 
Evening Primrose Oil

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Evening Primrose Oil
Evening Primrose Oil (EPO) is a rich natural source of Omega-6 essential fatty acids (EFAs), Gamma-linolenic Acid (GLA) and Linoleic Acid (LA). GLA is essential for production of prostaglandins, hormone-like substances, which regulate many important body functions including cholesterol levels, joint health, circulation and skin condition.
Ingredients: Organic Evening Primrose Oil 1000mg. Providing: Gamma-linolenic Acid (GLA) 100mg, Linoleic Acid (LA) 740mg, d-Alpha Tocopheryl (Vitamin E) 5iu. The organic, cold-pressed evening primrose oil used in this product is certified by the USDA National Organic Program and ECOCERT SA.
Suggested Use: Adults – Take 1-3 capsules daily with food, or as professionally prescribed.
References: Aragona P., Bucolo C., Spinella R., Giuffrida S., Ferreri G., Systemic omega-6 essential fatty acid treatment and pge1 tear content in Sjogren’s syndrome patients, Invest Ophthalmol Vis Sci. 2005 Dec; 46 (12): 4474-9. Belch J.J., Ansell D., Madhok R., O’Dowd A., Sturrock R.D., Effects of altering dietary essential fatty acids on requirements for non-steroidal anti-inflammatory drugs in patients with rheumatoid arthritis: a double blind placebo controlled study, Ann Rheum Dis. 1988 Feb; 47 (2): 96-104. Belch J.J., Shaw B., O’Dowd A., Saniabadi A., Leiberman P., Sturrock R.D., Forbes C.D., Evening primrose oil (Efamol) in the treatment of Raynaud’s phenomenon: a double blind study, Thromb Haemost. 1985 Aug 30; 54 (2): 490-4. Bordoni A., Biagi P.L., Masi M., Ricci G., Fanelli C., Patrizi A., Ceccolini E., Evening primrose oil (Efamol) in the treatment of children with atopic eczema, Drugs Exp Clin Res. 1988; 14 (4): 291-7. Brzeski M., Madhok R., Capell H.A., Evening primrose oil in patients with rheumatoid arthritis and side effects of non-steroidal anti-inflammatory drugs, Br J Rheumatol. 1991 Oct; 30 (5): 370-2. Cheng Z., Abayasekara D.R., Wathes D.C., The effect of supplementation with n-6 polyunsaturated fatty acids on 1-,2-, and 3-series prostaglandin F production by ovine uterine epithelial cells, Biochim Biophys Acta. 2005 Sep 15; 1736 (2): 128-35. Cheung K.L., Management of cyclical mastalgia in oriental women: pioneer experience of using gamolenic acid (Efamast) in Asia, Aust N Z J Surg. 1999 Jul; 69 (7): 492-4. Dippenaar N., Booyens J., Fabbri D., Katzef I.E., The reversibility of cancer: evidence that malignancy in melanoma cells is gamma-linolenic acid deficiency-dependent, S Afr Med J. 1982 Oct 2; 62 (15): 505-9. Engler M.M., Comparative study of diets enriched with evening primrose, black currant, borage or fungal oils on blood pressure and pressor responses in spontaneously hypertensive rats, Prostaglandins Leukot Essent Fatty Acids. 1993 Oct; 49 (4): 809-14. Greenfield S.M., Green A.T., Teare J.P., Jenkins A.P., Punchard N.A., Ainley C.C. Thompson R.P., A randomized controlled study of evening primrose oil and fish oil in ulcerative colitis, Aliment Pharmacol Ther. 1993 Apr; 7 (2): 159-66. GNC Healthnotes: htpp://www.gnc.com Hornych A., Oravec S., Girault F., Forette B., Horrobin D.F., The effect of gamma-linolenic acid on plasma and membrane lipids and renal prostaglandin synthesis in older subjects, Bratisl Lek Listy. 2002; 103 (3): 101-7. Horrobin D.F., Essential fatty acid and prostaglandin metabolism in Sjogren’s syndrome, systemic sclerosis and rheumatoid arthritis, Scand J Rheumatol Suppl. 1986; 61: 242-5. Horrobin D.F., Essential fatty acid metabolism and its modification in atopic eczema, Am J Clin Nutr. 2000 Jan; 71 (1 Supple): 367S-72S. Horrobin D.F., Prostaglandin E1: physiological significance and clinical use, Wien Klin Wochenschr. 1988 Jul 15; 100 (14): 471-7. Horrobin D.F., The relationship between schizophrenia and essential fatty acid and eicosanoid metabolism, Prostaglandins Leukot Essent Fatty Acids. 1992 May; 46 (1): 71-7. Horrobin D.F., The role of essential fatty acids and prostaglandins in the premenstrual syndrome, J Reprod Med. 1983 Jul; 28 (7): 465-8. Horrobin D.F., Manku M.S., Oka M., Morgan R.O., Cunnane S.C., Ally A.I., Ghayur T., Schweitzer M., Karmali R.A., The nutritional regulation of T lymphocyte function, Med Hypotheses. 1979 Sep; 5 (9): 969-85. Ishikawa T., Fujiyama Y., Igarashi O., Morino M., Tada N., Kagami A., Sakamoto T., Nagano M., Nakamura H., Effects of gammalinolenic aicd on plasma lipoproteins and apolipoproteins, Atherosclerosis. 1989 Feb; 75 (2-3): 95-104. Jamal G.A., Carmichael H., The effect of gamma-linolenic acid on human diabetic peripheral neuropathy: a double-blind placebo-controlled trial, Diabet Med. 1990 May; 7 (4): 319-23. Schalin-Karrila M., Mattila L., Jansen C.T., Uotila P., Evening primrose oil in the treatment of atopic eczema: effect on clinical status, plasma phospholipids fatty acids and circulating blood prostaglandins, Br J Dermatol. 1987 Jul; 117 (1): 11-9. Vaddadi K.S., Use of gamma-linolenic acid in the treatment of schizophrenia and tardive dyskinesia, Prostaglandins Leukot Essent Fatty Acids. 1992 May; 46 (1): 67-70. Villalobos M.A., De La Cruz J.P., Martin-Romero M., Carmona J.A., Smith-Agreda J.M., Sanchez de la Cuesta F., Effect of dietary supplementation with evening primrose oil on vascular thrombogenesis in hyperlipemic rabbits, Thromb Haemost. 1998 Oct; 80 (4): 696-701. Watkins G., Martin T.A., Bryce R., Mansel R.E., Jiang W.G., Gamma-Linolenic acid regulates the expression and secretion of SPARC in human cancer cells, Prostaglandins Leukot Essent Fatty Acids. 2005 Apr; 72 (4): 273-8.
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Nutritional information contained here is based on research literature and published knowledge on nutrition. Any nutritional suggestions should not be taken as medical advice.